Emergency crews are responding to Interstate 81 N near mile marker 37 in Smyth County.
The slide is between Chilhowie and Seven Mile Ford.
Officials say a rockslide is blocking part of the travel lanes.
VDOT crews are on the way to clear the scene.
Virginia State Police are warning drivers to use caution in the area and expect delays until they get the travel lanes clear.
Viewers are telling News 5 the visibility in the area is limited and causing problems for drivers.
We will keep following this story.